Yes, you can set one home per world. If you move, or wish to make a new home, you can reset your home. However, this will cause your old /home to become invalid.
Make sure you’re in the right world when you type /home to get back to your house.
In addition, you can type /where to help find your home.
You can set your home with /sethome, make sure to type it where you want your home to be. Keep in mind, where you are standing when you type /sethome because this is the spot where you spawn when you use /home command. If you are in the air when you set your home (using /sethome), you will appear in the air when you use /home. If flying is not enabled, you could fall causing your toon to die. It’s important to remember where your home is as well.