Yes, you can set one home per world. If you move, or wish to make a new home, you can reset your home. However, this will cause your old /home to become invalid.
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Frequently Asked Question
How do I set my chest/door/furnace/dispenser so only certain people can access it?Use /cmodify [Person's name] then hit the chest/door/furnace/dispenser. This applies to other lockable things.
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